Pimozide suppresses cancer cell migration and tumor metastasis through binding to ARPC2, a subunit of the Arp2/3 complex

ARPC2 is a subunit of the Arp2/3 complex, which is essential for lamellipodia, invadopodia and filopodia, and ARPC2 has been identified as a migrastatic target molecule. To identify ARPC2 inhibitors, we generated an ARPC2 knockout DLD‐1 human colon cancer cell line using the clustered regularly inte...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Choi, Jiyeon, Lee, Yu‐Jin, Yoon, Yae Jin, Kim, Cheol‐Hee, Park, Seung‐Jin, Kim, Seon‐Young, Doo Kim, Nam, Cho Han, Dong, Kwon, Byoung‐Mog
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6890432/
https://ncbi.nlm.nih.gov/pubmed/31571309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14205
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