Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B(−/−) Mice

The neural substrates and pathophysiological mechanisms underlying the onset of cognitive and motor deficits in autism spectrum disorders (ASDs) remain unclear. Mutations in ASD-associated SHANK3 in mice (Shank3B(−/−)) result in the accelerated maturation of corticostriatal circuits during the secon...

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Vydáno v:Cell Rep
Hlavní autoři: Peixoto, Rui Tiago, Chantranupong, Lynne, Hakim, Richard, Levasseur, James, Wang, Wengang, Merchant, Tasha, Gorman, Kelly, Budnik, Bogdan, Sabatini, Bernardo Luis
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889826/
https://ncbi.nlm.nih.gov/pubmed/31722214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.10.021
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