The lytic activity of VSV-GP treatment dominates the therapeutic effects in a syngeneic model of lung cancer

BACKGROUND: Oncolytic virotherapy is thought to result in direct virus-induced lytic tumour killing and simultaneous activation of innate and tumour-specific adaptive immune responses. Using a chimeric vesicular stomatitis virus variant VSV-GP, we addressed the direct oncolytic effects and the role...

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Pubblicato in:Br J Cancer
Autori principali: Schreiber, Liesa-Marie, Urbiola, Carles, Das, Krishna, Spiesschaert, Bart, Kimpel, Janine, Heinemann, Fabian, Stierstorfer, Birgit, Müller, Philipp, Petersson, Monika, Erlmann, Patrik, von Laer, Dorothee, Wollmann, Guido
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889376/
https://ncbi.nlm.nih.gov/pubmed/31530903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0574-7
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