Immune checkpoint inhibitors for the treatment of MSI-H/MMR-D colorectal cancer and a perspective on resistance mechanisms

Metastatic colorectal cancer (CRC) with a mismatch repair-deficiency (MMR-D)/microsatellite instability-high (MSI-H) phenotype carries unique characteristics such as increased tumour mutational burden and tumour-infiltrating lymphocytes. Studies have shown a sustained clinical response to immune che...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Sahin, Ibrahim Halil, Akce, Mehmet, Alese, Olatunji, Shaib, Walid, Lesinski, Gregory B., El-Rayes, Bassel, Wu, Christina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889302/
https://ncbi.nlm.nih.gov/pubmed/31607751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0599-y
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