Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages

BACKGROUND: The progression and metastasis of pancreatic ductal adenocarcinoma (PDAC) is highly dependent on the tumour microenvironment. Most tumour-associated macrophages (TAMs) are M2 phenotype macrophages, which normally show anti-inflammatory functions in numerous disorders. Previously, we foun...

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Veröffentlicht in:Br J Cancer
Hauptverfasser: Chen, Qi, Wang, Jianxin, Zhang, Qi, Zhang, Jingying, Lou, Yu, Yang, Jiaqi, Chen, Yiwen, Wei, Tao, Zhang, Jian, Fu, Qihan, Ye, Mao, Zhang, Xiaozhen, Dang, Xiaowei, Liang, Tingbo, Bai, Xueli
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889176/
https://ncbi.nlm.nih.gov/pubmed/31588122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0595-2
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