Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers

Cancer cells frequently boost nucleotide metabolism (NM) to support their increased proliferation, but the consequences of elevated NM on tumor de-differentiation are mostly unexplored. Here, we identified a role for thymidylate synthase (TS), a NM enzyme and established drug target, in cancer cell...

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Bibliographic Details
Published in:Cell Death Differ
Main Authors: Siddiqui, Aarif, Gollavilli, Paradesi Naidu, Schwab, Annemarie, Vazakidou, Maria Eleni, Ersan, Pelin G., Ramakrishnan, Mallika, Pluim, Dick, Coggins, Si’Ana, Saatci, Ozge, Annaratone, Laura, HM Schellens, Jan, Kim, Baek, Asangani, Irfan Ahmed, Rasheed, Suhail Ahmed Kabeer, Marchiò, Caterina, Sahin, Ozgur, Ceppi, Paolo
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6888897/
https://ncbi.nlm.nih.gov/pubmed/30737477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0289-6
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