Liver‐Targeted Angiotensin Converting Enzyme 2 Therapy Inhibits Chronic Biliary Fibrosis in Multiple Drug‐Resistant Gene 2‐Knockout Mice

There is a large unmet need for effective therapies for cholestatic disorders, including primary sclerosing cholangitis (PSC), a disease that commonly results in liver failure. Angiotensin (Ang) II of the renin Ang system (RAS) is a potent profibrotic peptide, and Ang converting enzyme 2 (ACE2) of t...

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Bibliografiske detaljer
Udgivet i:Hepatol Commun
Main Authors: Rajapaksha, Indu G., Gunarathne, Lakmie S., Asadi, Khashayar, Cunningham, Sharon C., Sharland, Alexandra, Alexander, Ian E., Angus, Peter W., Herath, Chandana B.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887688/
https://ncbi.nlm.nih.gov/pubmed/31832573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1434
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