Inhibiting nucleolin reduces inflammation induced by mitochondrial DNA in cardiomyocytes exposed to hypoxia and reoxygenation

BACKGROUND AND PURPOSE: Cellular debris causes sterile inflammation after myocardial infarction. Mitochondria constitute about 30 percent of the human heart. Mitochondrial DNA (mtDNA) is a damage‐associated‐molecular‐pattern that induce injurious sterile inflammation. Little is known about mtDNA...

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Udgivet i:Br J Pharmacol
Main Authors: Mariero, Lars Henrik, Torp, May‐Kristin, Heiestad, Christina Mathisen, Baysa, Anton, Li, Yuchuan, Valen, Guro, Vaage, Jarle, Stensløkken, Kåre‐Olav
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
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Themed Section: Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887679/
https://ncbi.nlm.nih.gov/pubmed/31412132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14830
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