PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC

PTPRS is the most commonly mutated receptor tyrosine phosphatase in colorectal cancer (CRC). PTPRS has been shown to directly affect ERK and regulate its activation and nuclear localization. Here we identify that PTPRS may play a significant role in developing adaptive resistance to MEK/ERK inhibito...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Davis, Thomas B., Yang, Mingli, Wang, Heiman, Lee, Changgong, Yeatman, Timothy J., Pledger, W. Jack
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2019
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887575/
https://ncbi.nlm.nih.gov/pubmed/31827720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27335
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