Efficacy of sofosbuvir as treatment for yellow fever: protocol for a randomised controlled trial in Brazil (SOFFA study)

INTRODUCTION: An ongoing outbreak of yellow fever (YF) has been reported in Brazil with 1261 confirmed cases and 409 deaths since July 2017. To date, there is no specific treatment available for YF. Recently published papers describing in vitro and animal models suggest a potential effect of antivir...

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Pubblicato in:BMJ Open
Autori principali: Figueiredo-Mello, Claudia, Casadio, Luciana Vilas Boas, Avelino-Silva, Vivian Iida, Yeh-Li, Ho, Sztajnbok, Jaques, Joelsons, Daniel, Antonio, Marilia Bordignon, Pinho, João Renato Rebello, Malta, Fernanda de Mello, Gomes-Gouvêa, Michele Soares, Salles, Ana Paula Moreira, Corá, Aline Pivetta, Moreira, Carlos Henrique Valente, Ribeiro, Ana Freitas, Nastri, Ana Catharina de Seixas Santos, Malaque, Ceila Maria Sant'Ana, Teixeira, Ralcyon Francis Azevedo, Borges, Luciana Marques Sansão, Gonzalez, Mario Peribañez, Junior, Luiz Carlos Pereira, Souza, Tâmara Newman Lobato, Song, Alice Tung Wan, D'Albuquerque, Luiz Augusto Carneiro, Abdala, Edson, Andraus, Wellington, de Martino, Rodrigo Bronze, Ducatti, Liliana, Andrade, Guilherme Marques, Malbouisson, Luiz Marcelo Sá, de Souza, Izabel Marcilio, Carrilho, Flair José, Sabino, Ester Cerdeira, Levin, Anna S
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2019
Soggetti:
Infectious Diseases
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887076/
https://ncbi.nlm.nih.gov/pubmed/31772079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2018-027207
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