Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S

Precision medicine has revolutionized the treatment of patients in EGFR driven non-small cell lung cancer (NSCLC). Targeted drugs show high response rates in genetically defined subsets of cancer patients and markedly increase their progression-free survival as compared to conventional chemotherapy....

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Udgivet i:Chem Sci
Main Authors: Lategahn, Jonas, Keul, Marina, Klövekorn, Philip, Tumbrink, Hannah L., Niggenaber, Janina, Müller, Matthias P., Hodson, Luke, Flaßhoff, Maren, Hardick, Julia, Grabe, Tobias, Engel, Julian, Schultz-Fademrecht, Carsten, Baumann, Matthias, Ketzer, Julia, Mühlenberg, Thomas, Hiller, Wolf, Günther, Georgia, Unger, Anke, Müller, Heiko, Heimsoeth, Alena, Golz, Christopher, Blank-Landeshammer, Bernhard, Kollipara, Laxmikanth, Zahedi, René P., Strohmann, Carsten, Hengstler, Jan G., van Otterlo, Willem A. L., Bauer, Sebastian, Rauh, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2019
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6886544/
https://ncbi.nlm.nih.gov/pubmed/31857889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc03445e
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