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Lamins organize the global three-dimensional genome from the nuclear periphery
Lamins are structural components of the nuclear lamina (NL) that regulate genome organization and gene expression, but the mechanism remains unclear. Using Hi-C, we show that lamins maintain proper interactions among the topologically associated chromatin domains (TADs) but not their overall archite...
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| Publicado en: | Mol Cell |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6886264/ https://ncbi.nlm.nih.gov/pubmed/30201095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.05.017 |
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