Pembrolizumab and platinum-based chemotherapy as first-line therapy for advanced non–small-cell lung cancer: Phase 1 cohorts from the KEYNOTE-021 study

OBJECTIVES: Platinum-based chemotherapy for advanced non–small-cell lung cancer (NSCLC) has modest benefit overall, but has the potential to amplify immune responses. In cohorts A-C of the multicohort phase 1/2 study KEYNOTE-021 (Clinicaltrials.gov, ), we evaluated combinations of platinum-doublet c...

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Dettagli Bibliografici
Pubblicato in:Lung Cancer
Autori principali: Gadgeel, Shirish M., Stevenson, James P., Langer, Corey J., Gandhi, Leena, Borghaei, Hossein, Patnaik, Amita, Villaruz, Liza C., Gubens, Matthew, Hauke, Ralph, Yang, James Chih-Hsin, Sequist, Lecia V., Bachman, Robert, Saraf, Sanatan, Raftopoulos, Harry, Papadimitrakopoulou, Vassiliki
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6886233/
https://ncbi.nlm.nih.gov/pubmed/30429032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2018.08.019
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