Metformin Suppresses Self-Renewal Ability and Tumorigenicity of Osteosarcoma Stem Cells via Reactive Oxygen Species-Mediated Apoptosis and Autophagy

Osteosarcoma is the most frequently diagnosed primary malignant bone sarcoma in children and adolescents. Recent studies have shown that cancer stem cells (CSCs), a cluster of tumor cells with the ability to self-renew, play an essential role in tumor recurrence and metastasis. Thus, it is necessary...

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Detalles Bibliográficos
Publicado en:Oxid Med Cell Longev
Autores principales: Zhao, Bin, Luo, Jie, Wang, Ye, Zhou, Liangfu, Che, Jingmin, Wang, Fang, Peng, Songlin, Zhang, Ge, Shang, Peng
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885828/
https://ncbi.nlm.nih.gov/pubmed/31827709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/9290728
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