Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy

In diabetic neuropathy, there is activation of axonal and sensory neuronal degeneration pathways leading to distal axonopathy. The nicotinamide-adenine dinucleotide (NAD(+))-dependent deacetylase enzyme, Sirtuin 1 (SIRT1), can prevent activation of these pathways and promote axonal regeneration. In...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Chandrasekaran, Krish, Salimian, Mohammad, Konduru, Sruthi R, Choi, Joungil, Kumar, Pranith, Long, Aaron, Klimova, Nina, Ho, Cheng-Ying, Kristian, Tibor, Russell, James W
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885680/
https://ncbi.nlm.nih.gov/pubmed/31754701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awz324
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