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Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy
In diabetic neuropathy, there is activation of axonal and sensory neuronal degeneration pathways leading to distal axonopathy. The nicotinamide-adenine dinucleotide (NAD(+))-dependent deacetylase enzyme, Sirtuin 1 (SIRT1), can prevent activation of these pathways and promote axonal regeneration. In...
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| Publié dans: | Brain |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6885680/ https://ncbi.nlm.nih.gov/pubmed/31754701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awz324 |
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