Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study

Early diagnosis of leprosy is challenging, particularly its inflammatory reactions, the major cause of irreversible neuropathy in leprosy. Current diagnostics cannot identify which patients are at risk of developing reactions. This study assessed blood RNA expression levels as potential biomarkers f...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Tió-Coma, Maria, van Hooij, Anouk, Bobosha, Kidist, van der Ploeg-van Schip, Jolien J., Banu, Sayera, Khadge, Saraswoti, Thapa, Pratibha, Kunwar, Chhatra B., Goulart, Isabela M., Bekele, Yonas, Hagge, Deanna A., Moraes, Milton O., Teles, Rosane M. B., Pinheiro, Roberta Olmo, van Zwet, Erik W., Goeman, Jelle J., Aseffa, Abraham, Haks, Mariëlle C., Ottenhoff, Tom H. M., Modlin, Robert L., Geluk, Annemieke
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884598/
https://ncbi.nlm.nih.gov/pubmed/31784594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54213-y
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