Functional maturation of human neural stem cells in a 3D bioengineered brain model enriched with fetal brain-derived matrix

Brain extracellular matrix (ECM) is often overlooked in vitro brain tissue models, despite its instructive roles during development. Using developmental stage-sourced brain ECM in reproducible 3D bioengineered culture systems, we demonstrate enhanced functional differentiation of human induced neura...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sood, Disha, Cairns, Dana M., Dabbi, Jayanth M., Ramakrishnan, Charu, Deisseroth, Karl, Black, Lauren D., Santaniello, Sabato, Kaplan, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6884597/
https://ncbi.nlm.nih.gov/pubmed/31784595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54248-1
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