Impact Of Penetratin Stereochemistry On The Oral Bioavailability Of Insulin-Loaded Solid Lipid Nanoparticles

PURPOSE: This study evaluated the stereoisomeric effect of L- and D-penetratin—cell-penetrating peptides (CPPs)—incorporated insulin-loaded solid lipid nanoparticles (INS-SLNs) on the bioavailability (BA) of oral insulin (INS). METHODS: Insulin-loaded solid nanoparticles, L-penetratin-INS-SLNs (LP-I...

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Detalles Bibliográficos
Publicado en:Int J Nanomedicine
Main Authors: Alsulays, Bader B, Anwer, Md Khalid, Soliman, Gamal A, Alshehri, Sultan M, Khafagy, El-Sayed
Formato: Artigo
Idioma:Inglês
Publicado: Dove 2019
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883942/
https://ncbi.nlm.nih.gov/pubmed/31819423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S225086
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