Defining genetic variation in widely used congenic and backcrossed mouse models reveals varied regulation of genes important for immune responses

Genetic variation influences how the genome is interpreted in individuals and in mouse strains used to model immune responses. We developed approaches to utilize next-generation sequencing datasets to identify sequence variation in genes and enhancer elements in congenic and backcross mouse models....

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Veröffentlicht in:Immunity
Hauptverfasser: Chisolm, Danielle A., Cheng, Wayne, Colburn, Shelby A., Silva-Sanchez, Aaron, Meza-Perez, Selene, Randall, Troy D., Weinmann, Amy S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883924/
https://ncbi.nlm.nih.gov/pubmed/31248780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.05.006
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