Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury

BACKGROUND: Spinal cord injury induces inflammatory responses that include the release of cytokines and the recruitment and activation of macrophages and microglia. Neuroinflammation at the lesion site contributes to secondary tissue injury and permanent locomotor dysfunction. Dexmedetomidine (DEX),...

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Detalhes bibliográficos
Publicado no:Br J Anaesth
Main Authors: Gao, Jiandong, Sun, Zhihua, Xiao, Zhaoyang, Du, Qihang, Niu, Xinhuan, Wang, Gongming, Chang, Yu-Wen, Sun, Yongtao, Sun, Wei, Lin, Amity, Bresnahan, Jacqueline C., Maze, Mervyn, Beattie, Michael S., Pan, Jonathan Z.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Neuroscience and Neuroanaesthesia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883489/
https://ncbi.nlm.nih.gov/pubmed/31623841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2019.08.026
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