Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine

Human postmortem studies suggest a major role for abnormalities in GABAergic interneurons in the prefrontal cortex in schizophrenia. Cortical interneurons differentiated from induced pluripotent stem cells (iPSCs) of schizophrenia subjects showed significantly lower levels of glutamate decarboxylase...

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Vydáno v:Transl Psychiatry
Hlavní autoři: Kathuria, Annie, Lopez-Lengowski, Kara, Watmuff, Bradley, McPhie, Donna, Cohen, Bruce M., Karmacharya, Rakesh
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6882825/
https://ncbi.nlm.nih.gov/pubmed/31780643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-019-0660-x
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