Characterization of genetic subclonal evolution in pancreatic cancer mouse models

The KPC mouse model, driven by the Kras and Trp53 transgenes, is well regarded for faithful recapitulation of human pancreatic cancer biology. However, the extent that this model recapitulates the subclonal evolution of this tumor type is unknown. Here we report evidence of continuing subclonal evol...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Niknafs, Noushin, Zhong, Yi, Moral, John Alec, Zhang, Lance, Shao, Melody Xiaoshan, Lo, April, Makohon-Moore, Alvin, Iacobuzio-Donahue, Christine A., Karchin, Rachel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6882784/
https://ncbi.nlm.nih.gov/pubmed/31780749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13100-w
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