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Impaired Intestinal Farnesoid X Receptor Signaling in Cystic Fibrosis Mice
BACKGROUND & AIMS: The bile acid (BA)-activated farnesoid X receptor (FXR) controls hepatic BA synthesis and cell proliferation via the intestinal hormone fibroblast growth factor 19. Because cystic fibrosis (CF) is associated with intestinal dysbiosis, anomalous BA handling, and biliary cirrhos...
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| Publicat a: | Cell Mol Gastroenterol Hepatol |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6881665/ https://ncbi.nlm.nih.gov/pubmed/31470114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2019.08.006 |
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