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miR-221 Augments TRAIL-Mediated Apoptosis in Prostate Cancer Cells by Inducing Endogenous TRAIL Expression and Targeting the Functional Repressors SOCS3 and PIK3R1

miR-221 is regarded as an oncogene in many malignancies, and miR-221-mediated resistance towards TRAIL was one of the first oncogenic roles shown for this small noncoding RNA. In contrast, miR-221 is downregulated in prostate cancer (PCa), thereby implying a tumour suppressive function. By using pro...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Biomed Res Int
Main Authors: Krebs, Markus, Behrmann, Christoph, Kalogirou, Charis, Sokolakis, Ioannis, Kneitz, Susanne, Kruithof-de Julio, Marianna, Zoni, Eugenio, Rech, Anne, Schilling, Bastian, Kübler, Hubert, Spahn, Martin, Kneitz, Burkhard
פורמט: Artigo
שפה:Inglês
יצא לאור: Hindawi 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6881584/
https://ncbi.nlm.nih.gov/pubmed/31828111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/6392748
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