Tumor-derived Thymic stromal lymphopoietin expands bone marrow B-cell precursors in circulation to support metastasis

Immature B cells in the bone marrow (BM) emigrate into the spleen during adult lymphopoiesis. Here, we report that emigration is shifted to earlier B-cell stages in mice with orthotopic breast cancer, spontaneous ovarian cancer, and possibly in human breast carcinoma. Using mouse and human BM aspira...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Ragonnaud, Emeline, Moritoh, Kanako, Bodogai, Monica, Gusev, Fedor, Garaud, Soizic, Chen, Chen, Wang, Xin, Baljinnyam, Tuvshintugs, Becker, Kevin G., Maul, Robert W., Willard-Gallo, Karen, Rogaev, Evgeny, Biragyn, Arya
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6881554/
https://ncbi.nlm.nih.gov/pubmed/31575547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1058
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