Evidence for enhanced Bruton’s tyrosine kinase activity in transitional and naïve B cells of patients with granulomatosis with polyangiitis

OBJECTIVES: To determine Bruton’s tyrosine kinase (BTK) protein and phosphorylation levels in B cell subsets of granulomatosis with polyangiitis (GPA) patients and to investigate the effect of BTK blockade on in vitro B cell cytokine production, subset distribution and (auto)antibody production. MET...

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Udgivet i:Rheumatology (Oxford)
Main Authors: von Borstel, Anouk, Abdulahad, Wayel H, Sanders, Jan Stephan, Rip, Jasper, Neys, Stefan F H, Hendriks, Rudi W, Stegeman, Coen A, Heeringa, Peter, Rutgers, Abraham, Corneth, Odilia B J
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Clinical Science
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6880857/
https://ncbi.nlm.nih.gov/pubmed/31209475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/kez205
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