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Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate

Growth rate and metabolic state of bacteria have been separately shown to affect antibiotic efficacy(1–3). However, the two are interrelated as bacterial growth inherently imposes a metabolic burden(4); thus, determining individual contributions from each is challenging(5,6). Indeed, faster growth i...

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Detalhes bibliográficos
Publicado no:Nat Microbiol
Main Authors: Lopatkin, Allison J., Stokes, Jonathan M., Zheng, Erica J., Yang, Jason H., Takahashi, Melissa K., You, Lingchong, Collins, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879803/
https://ncbi.nlm.nih.gov/pubmed/31451773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-019-0536-0
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