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Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling

Potassium channels are presumed to have two allosterically coupled gates, the activation gate and the selectivity filter gate, that control channel opening, closing, and inactivation. However, the molecular mechanism of how these gates regulate K(+ )ion flow through the channel remains poorly unders...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Kopec, Wojciech, Rothberg, Brad S., de Groot, Bert L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879586/
https://ncbi.nlm.nih.gov/pubmed/31772184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13227-w
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