Ligand-induced disorder-to-order transitions characterized by structural proteomics and molecular dynamics simulations

For disordered proteins, ligand binding can be a critical event that changes their structural dynamics. The ability to characterize such changes would facilitate the development of drugs designed to stabilize disordered proteins, whose mis-folding is important for a number of pathologies, including...

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Publicado no:J Proteomics
Main Authors: Makepeace, Karl A.T., Brodie, Nicholas I., Popov, Konstantin I., Gudavicius, Geoff, Nelson, Christopher J., Petrotchenko, Evgeniy V., Dokholyan, Nikolay V., Borchers, Christoph H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6878985/
https://ncbi.nlm.nih.gov/pubmed/31683063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jprot.2019.103544
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