Effectiveness and selectivity of a heroin conjugate vaccine to attenuate heroin, 6-acetylmorphine, and morphine antinociception in rats: Comparison with naltrexone

BACKGROUND: One emerging strategy to address the opioid crisis includes opioid-targeted immunopharmacotherapies. This study compared effectiveness of a heroin-tetanus toxoid (TT) conjugate vaccine to antagonize heroin, 6-acetylmorphine (6-AM), morphine, and fentanyl antinociception in rats. METHODS:...

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Detalhes bibliográficos
Publicado no:Drug Alcohol Depend
Main Authors: Schwienteck, Kathryn L., Blake, Steven, Bremer, Paul T., Poklis, Justin L., Townsend, E. Andrew, Negus, S. Stevens, Banks, Matthew L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6878171/
https://ncbi.nlm.nih.gov/pubmed/31479865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2019.06.006
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