HLA-B27–mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis

Ankylosing spondylitis (AS) is a type of axial inflammation. Over time, some patients develop spinal ankylosis and permanent disability; however, current treatment strategies cannot arrest syndesmophyte formation completely. Here, we used mesenchymal stem cells (MSCs) from AS patients (AS MSCs) with...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Liu, Chin-Hsiu, Raj, Sengupta, Chen, Chun-Hsiung, Hung, Kuo-Hsuan, Chou, Chung-Tei, Chen, Ing-Ho, Chien, Jui-Teng, Lin, I-Ying, Yang, Shii-Yi, Angata, Takashi, Tsai, Wen-Chan, Wei, James Cheng-Chung, Tzeng, I-Shiang, Hung, Shih-Chieh, Lin, Kuo-I
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877322/
https://ncbi.nlm.nih.gov/pubmed/31682238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125212
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