Adverse vascular risk relates to cerebrospinal fluid biomarker evidence of axonal injury in the presence of Alzheimer’s disease pathology

BACKGROUND: Vascular risk factors promote cerebral small vessel disease and neuropathological changes, particularly in white matter where large-caliber axons are located. How Alzheimer’s pathology influences the brain’s vulnerability in this regard is not well understood. OBJECTIVE: Systemic vascula...

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Pubblicato in:J Alzheimers Dis
Autori principali: Osborn, Katie E., Alverio, Jonathan M., Dumitrescu, Logan, Pechman, Kimberly R., Gifford, Katherine A., Hohman, Timothy J., Blennow, Kaj, Zetterberg, Henrik, Jefferson, Angela L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877290/
https://ncbi.nlm.nih.gov/pubmed/31381510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-190077
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