Recreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanism

The human host comprises a range of specific niche environments. In order to successfully persist, pathogens such as Aspergillus fumigatus must adapt to these environments. One key example of in-host adaptation is the development of resistance to azole antifungals. Azole resistance in A. fumigatus i...

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Publicado en:Fungal Genet Biol
Autores principales: Ballard, Eloise, Weber, Jakob, Melchers, Willem J.G., Tammireddy, Seshu, Whitfield, Phillip D., Brakhage, Axel A., Brown, Alistair J.P., Verweij, Paul E., Warris, Adilia
Formato: Artigo
Lenguaje:Inglês
Publicado: Academic Press 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876285/
https://ncbi.nlm.nih.gov/pubmed/31128273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fgb.2019.05.005
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