SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer

Mitochondrial superoxide dismutase (SOD2) suppresses tumor initiation but promotes invasion and dissemination of tumor cells at later stages of the disease. The mechanism of this functional switch remains poorly defined. Our results indicate that as SOD2 expression increases acetylation of lysine 68...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: He, Chenxia, Danes, Jeanne M., Hart, Peter C., Zhu, Yueming, Huang, Yunping, de Abreu, Andre Luelsdorf, O’Brien, Joseph, Mathison, Angela J., Tang, Binwu, Frasor, Jonna M., Wakefield, Lalage M., Ganini, Douglas, Stauder, Erich, Zielonka, Jacek, Gantner, Benjamin N., Urrutia, Raul A., Gius, David, Bonini, Marcelo G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876149/
https://ncbi.nlm.nih.gov/pubmed/31591207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902308116
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