Enhanced p62-NRF2 Feedback Loop due to Impaired Autophagic Flux Contributes to Arsenic-Induced Malignant Transformation of Human Keratinocytes

Chronic exposure to arsenic induces a variety of cancers, particularly in the skin. Autophagy is a highly conserved process which plays a dual role in tumorigenesis. In the present study, we found that chronic exposure to an environmentally relevant dose of arsenite induced malignant transformation...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Wu, Xiafang, Sun, Ru, Wang, Huihui, Yang, Bei, Wang, Fang, Xu, Hongtao, Chen, Shimin, Zhao, Rui, Pi, Jingbo, Xu, Yuanyuan
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6875345/
https://ncbi.nlm.nih.gov/pubmed/31781319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/1038932
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