In Utero Exposure to Gestational Diabetes Alters DNA Methylation and Gene Expression of CDKN2A/B in Langerhans Islets of Rat Offspring

OBJECTIVE: DNA methylation, a major epigenetic reprogramming mechanism, contributes to the increased prevalence of type 2 diabetes mellitus (T2DM). Based on genome-wide association studies, polymorphisms in CDKN2A/B are associated with T2DM. Our previous studies showed that gestational diabetes mell...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell J
Päätekijät: Nazari, Zahra, Shahryari, Alireza, Ghafari, Soraya, Nabiuni, Mohammad, Golalipour, Mohammad Jafar
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Royan Institute 2020
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874789/
https://ncbi.nlm.nih.gov/pubmed/31721535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22074/cellj.2020.6699
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