Fabrication of Second Generation Smarter PLGA Based Nanocrystal Carriers for Improvement of Drug Delivery and Therapeutic Efficacy of Gliclazide in Type-2 Diabetes Rat Model

Drug delivery and therapeutic challenges of gliclazide, a BCS class II drug used in type 2 diabetes mellitus (T2DM) can be overcome by exploring smarter carriers of second-generation nanocrystals (SGNCs). A combined method of emulsion diffusion, high-pressure homogenization and solvent evaporation m...

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Published in:Sci Rep
Main Authors: Panda, Bibhu Prasad, Krishnamoorthy, Rachna, Bhattamisra, Subrat Kumar, Shivashekaregowda, Naveen Kumar Hawala, Seng, Low Bin, Patnaik, Sujata
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874704/
https://ncbi.nlm.nih.gov/pubmed/31758056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53996-4
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