Histone deacetylase inhibitors with high in vitro activities against Plasmodium falciparum isolates collected from Gabonese children and adults

Histone deacetylase (HDAC) enzymes are targets for the development of antimalarial drugs with a different mode of action to established antimalarials. Broad-spectrum HDAC-inhibitors show high potency against Plasmodium falciparum, but displayed some toxicity towards human cells. Inhibitors of human...

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Pubblicato in:Sci Rep
Autori principali: Koehne, Erik, Kreidenweiss, Andrea, Zoleko Manego, Rella, McCall, Matthew, Mombo-Ngoma, Ghyslain, Mackwitz, Marcel Karl Walter, Hansen, Finn K., Held, Jana
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874535/
https://ncbi.nlm.nih.gov/pubmed/31758015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53912-w
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