Pre-metastatic niche triggers SDF-1/CXCR4 axis and promotes organ colonisation by hepatocellular circulating tumour cells via downregulation of Prrx1

BACKGROUND: Circulating tumour cells (CTCs), especially mesenchymal CTCs, are important determinants of metastasis, which leads to most recurrence and mortality in hepatocellular carcinoma (HCC). However, little is known about the underlying mechanisms of CTC colonisation in pre-metastatic niches. M...

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Bibliografski detalji
Izdano u:J Exp Clin Cancer Res
Glavni autori: Tang, Yujun, Lu, Yishi, Chen, Yuan, Luo, Lei, Cai, Lei, Peng, Bangjian, Huang, Wenbin, Liao, Hangyu, Zhao, Liang, Pan, Mingxin
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6873584/
https://ncbi.nlm.nih.gov/pubmed/31752959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1475-6
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