Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome

People with Down syndrome (DS; trisomy 21) display a different disease spectrum relative to the general population, including lower rates of solid malignancies and higher incidence of neurological and autoimmune conditions. However, the mechanisms driving this unique clinical profile await elucidati...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Waugh, Katherine A., Araya, Paula, Pandey, Ahwan, Jordan, Kimberly R., Smith, Keith P., Granrath, Ross E., Khanal, Santosh, Butcher, Eric T., Estrada, Belinda Enriquez, Rachubinski, Angela L., McWilliams, Jennifer A., Minter, Ross, Dimasi, Tiana, Colvin, Kelley L., Baturin, Dmitry, Pham, Andrew T., Galbraith, Matthew D., Bartsch, Kyle W., Yeager, Michael E., Porter, Christopher C., Sullivan, Kelly D., Hsieh, Elena W., Espinosa, Joaquin M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6871766/
https://ncbi.nlm.nih.gov/pubmed/31722205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.10.038
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