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A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

In the human malaria vector Anopheles gambiae, the gene doublesex (Agdsx) encodes two alternatively spliced transcripts, dsx-female (AgdsxF) and dsx-male (AgdsxM), that control differentiation of the two sexes. The female transcript, unlike the male, contains an exon (exon 5) whose sequence is highl...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nat Biotechnol
Main Authors: Kyrou, Kyros, Hammond, Andrew M, Galizi, Roberto, Kranjc, Nace, Burt, Austin, Beaghton, Andrea K, Nolan, Tony, Crisanti, Andrea
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group US 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6871539/
https://ncbi.nlm.nih.gov/pubmed/30247490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4245
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