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A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

In the human malaria vector Anopheles gambiae, the gene doublesex (Agdsx) encodes two alternatively spliced transcripts, dsx-female (AgdsxF) and dsx-male (AgdsxM), that control differentiation of the two sexes. The female transcript, unlike the male, contains an exon (exon 5) whose sequence is highl...

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書目詳細資料
發表在:Nat Biotechnol
Main Authors: Kyrou, Kyros, Hammond, Andrew M, Galizi, Roberto, Kranjc, Nace, Burt, Austin, Beaghton, Andrea K, Nolan, Tony, Crisanti, Andrea
格式: Artigo
語言:Inglês
出版: Nature Publishing Group US 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6871539/
https://ncbi.nlm.nih.gov/pubmed/30247490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4245
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