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Allostatic Changes in the cAMP System Drive Opioid-Induced Adaptation in Striatal Dopamine Signaling

Opioids are powerful addictive agents that alter dopaminergic influence on reward signaling in medium spiny neurons (MSNs) of the nucleus accumbens. Repeated opioid exposure triggers adaptive changes, shifting reward valuation to the allostatic state underlying tolerance. However, the cellular subst...

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Detalles Bibliográficos
Publicado en:Cell Rep
Main Authors: Muntean, Brian S., Dao, Maria T., Martemyanov, Kirill A.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6871051/
https://ncbi.nlm.nih.gov/pubmed/31644915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.09.034
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