Inhibition of CREB‐mediated ZO‐1 and activation of NF‐κB‐induced IL‐6 by colonic epithelial MCT4 destroys intestinal barrier function

OBJECTIVE: Inflammatory bowel disease (IBD) is a disorder intestinal inflammation and impaired barrier function, associated with increased epithelial expression of monocarboxylate transporter 4 (MCT4). However, the specific non‐metabolic function and clinical relevance of MCT4 in IBD remain to be fu...

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Detalhes bibliográficos
Publicado no:Cell Prolif
Main Authors: Zhang, Shunxian, Xu, Wanfu, Wang, Hongli, Cao, Meiwan, Li, Musheng, Zhao, Junhong, Hu, Yan, Wang, Yaodong, Li, Songyu, Xie, Yuanwen, Chen, Guanhua, Liu, Ruitao, Cheng, Yang, Xu, Zhaohui, Zou, Kejian, Gong, Sitang, Geng, Lanlan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6869122/
https://ncbi.nlm.nih.gov/pubmed/31418947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12673
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