Recombinant human milk fat globule-EGF factor VIII (rhMFG-E8) as a therapy for sepsis after acute exposure to alcohol

BACKGROUND: Alcohol intake predisposes to infections and sepsis. Alcohol and sepsis inhibit the expression of milk fat globule epidermal growth factor-factor VIII (MFG-E8), a glycoprotein essential for optimal efferocytosis, resulting in the release of proinflammatory molecules and increased sepsis...

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Bibliographic Details
Published in:Mol Med
Main Authors: Chaung, Wayne W., Brenner, Max, Yen, Hao-Ting, Ochani, Mahendar L., Jacob, Asha, Wang, Ping
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868720/
https://ncbi.nlm.nih.gov/pubmed/31747882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-019-0118-x
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