Automatic quantification of HER2 gene amplification in invasive breast cancer from chromogenic in situ hybridization whole slide images

Human epidermal growth factor receptor 2 (HER2), a transmembrane tyrosine kinase receptor encoded by the ERBB2 gene on chromosome 17q12, is a predictive and prognostic biomarker in invasive breast cancer (BC). Approximately 20% of BC are HER2-positive as a result of ERBB2 gene amplification and over...

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Udgivet i:J Med Imaging (Bellingham)
Main Authors: Hossain, Md. Shakhawat, Hanna, Matthew G., Uraoka, Naohiro, Nakamura, Tomoya, Edelweiss, Marcia, Brogi, Edi, Hameed, Meera R., Yamaguchi, Masahiro, Ross, Dara S., Yagi, Yukako
Format: Artigo
Sprog:Inglês
Udgivet: Society of Photo-Optical Instrumentation Engineers 2019
Fag:
Digital Pathology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868351/
https://ncbi.nlm.nih.gov/pubmed/31763355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1117/1.JMI.6.4.047501
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