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Engineering forward genetics into cultured cancer cells for chemical target identification
Target identification for biologically active small molecules remains a major barrier for drug discovery. Cancer cells exhibiting defective DNA mismatch repair (dMMR) have been used as a forward genetics system to uncover compound targets. However, this approach has been limited by the dearth of can...
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| Pubblicato in: | Cell Chem Biol |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6866228/ https://ncbi.nlm.nih.gov/pubmed/31303577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.06.006 |
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