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An aqueous normal-phase chromatography coupled with tandem mass spectrometry method for determining unbound brain-to-plasma concentration ratio of AZD1775, a Wee1 kinase inhibitor, in patients with glioblastoma
A rapid, sensitive, and robust aqueous normal-phase chromatography method coupled with tandem mass spectrometry was developed and validated for the quantitation of AZD1775, a Wee-1 inhibitor, in human plasma and brain tumor tissue. Sample preparation involved simple protein precipitation with aceton...
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| izdano v: | J Chromatogr B Analyt Technol Biomed Life Sci |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6863148/ https://ncbi.nlm.nih.gov/pubmed/27318641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2016.05.050 |
| Oznake: |
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