Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia

Trihexyphenidyl, a nonselective muscarinic receptor antagonist, is the small molecule drug of choice for the treatment of DYT1 dystonia, but it is poorly tolerated due to significant side effects. A better understanding of the mechanism of action of trihexyphenidyl is needed for the development of i...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Neurobiol Dis
Asıl Yazarlar: Downs, Anthony M., Fan, Xueliang, Donsante, Christine, Jinnah, H.A., Hess, Ellen J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863078/
https://ncbi.nlm.nih.gov/pubmed/30707939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.01.012
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