CHF6001 Inhibits NF-κB Activation and Neutrophilic Recruitment in LPS-Induced Lung Inflammation in Mice

Inhibitors of phosphodiesterase 4 (PDE4) are potent anti-inflammatory agents, inhibiting the production of inflammatory mediators through the elevation of intracellular cAMP concentrations. We studied the activity of a novel PDE4 inhibitor, CHF6001, both in vitro in human cells and in vivo, using bi...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Stellari, Fabio F., Sala, Angelo, Ruscitti, Francesca, Buccellati, Carola, Allen, Andrew, Risé, Patrizia, Civelli, Maurizio, Villetti, Gino
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863066/
https://ncbi.nlm.nih.gov/pubmed/31798449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01337
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