Identification of Gain and Loss of Function Missense Variants in MRGPRX2’s Transmembrane and Intracellular Domains for Mast Cell Activation by Substance P

The neuropeptide substance P (SP) contributes to neurogenic inflammation through the activation of human mast cells via Mas-related G protein-coupled receptor-X2 (MRGPRX2). Using pertussis toxins and YM-254890, we demonstrated that SP induces Ca(2+) mobilization and degranulation via both the Gαi an...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Chompunud Na Ayudhya, Chalatip, Roy, Saptarshi, Alkanfari, Ibrahim, Ganguly, Anirban, Ali, Hydar
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862462/
https://ncbi.nlm.nih.gov/pubmed/31652731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20215247
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